AXL-IN-13

AXL-IN-13

• CAS Number: 2376928-82-2
• UNSPSC Description: AXL-IN-13 is a potent and orally active AXL inhibitor (IC50: 1.6 nM, Kd: 0.26 nM). AXL-IN-13 reverses TGF-β1-induced epithelial-mesenchymal transition (EMT), and inhibits cancer cell migration and invasion[1].
• Target Antigen: FLT3; PDGFR; TAM Receptor
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/axl-in-13.html
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: COC1=C(C=C(C2=C1)N=CC=C2OC3=C(C=C(C=C3)NC4=NN(C=C4C(NC5CCCCC5)=O)C)F)OCCCN6CCOCC6
• Molecular Weight: 632.72
• References & Citations: [1]Chan S, et al. Discovery of 3-Aminopyrazole Derivatives as New Potent and Orally Bioavailable AXL Inhibitors. J Med Chem. 2022 Nov 24;65(22):15374-15390.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported