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DRD2 rabbit pAb

CAT: 0855-ES11460-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11460-02Size:100 µL
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Background
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Description
This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008],
UniProt
P14416
Swiss Prot
P14416
Reactivity
Human; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 170-250
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
48kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
48kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein .
Gene ID (Human)
1813

UniProtKB · P14416

Dopamine receptor D2

DRD2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P14416
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DRD2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q9NZR3, Q9UPA9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneGolgi apparatusMembranePostsynaptic cell membraneSynapse

PTM

Disulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

Domain

TransmembraneTransmembrane helix

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