GITR Extracellular Domain (human, recombinant)

• Description:

  GITR Extracellular Domain (human, recombinant)_x000D_ Catalog number: B2017354_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 100 µg_x000D_ Molecular Weight or Concentration: 16 kDa_x000D_ Supplied as: Powder_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: ˆ’80°C_x000D_ Keywords: CD357, GITR-D, Glucocorticoid-induced TNFR-related Protein, TNF Receptor Superfamily Member 18, TNFRS18, Tumor Necrosis Factor Receptor Superfamily Member 18_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Tigue NJ, Bamber L, Andrews J, Ireland S, Hair J, Carter E, Sridharan S, Jovanović J, Rees DG, Springall JS, Solier E, Li YM, Chodorge M, Perez-Martinez D, Higazi DR, Oberst M, Kennedy M, Black CM, Yan L, Schwickart M, Maguire S, Cann JA, de Haan L, Young LL, Vaughan T, Wilkinson RW, Stewart R. MEDI1873, a potent, stabilized hexameric agonist of human GITR with regulatory T-cell targeting potential Oncoimmunology. 2017 Feb 3;6(3):e1280645._x000D_ 2: Kim YH, Shin SM, Choi BK, Oh HS, Kim CH, Lee SJ, Kim KH, Lee DG, Park SH, Kwon BS. Authentic GITR Signaling Fails To Induce Tumor Regression unless Foxp3+ Regulatory T Cells Are Depleted J Immunol. 2015 Nov 15;195(10):4721-9._x000D_ 3: Draghiciu O, Lubbers J, Nijman HW, Daemen T. Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy Oncoimmunology. 2015 Feb 3;4(1):e954829._x000D_ 4: Morillon YM 2nd, Hammond SA, Durham NM, Schlom J, Greiner JW. Enhanced immunotherapy by combining a vaccine with a novel murine GITR ligand fusion protein Oncotarget. 2017 Sep 7;8(43):73469-73482._x000D_ 5: Nocentini G, Giunchi L, Ronchetti S, Krausz LT, Bartoli A, Moraca R, Migliorati G, Riccardi C. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6216-21._x000D_ 6: Zhou Z, Song X, Berezov A, Zhang G, Li Y, Zhang H, Murali R, Li B, Greene MI. Human glucocorticoid-induced TNF receptor ligand regulates its signaling activity through multiple oligomerization states Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5465-70._x000D_ 7: Shin HH, Lee MH, Kim SG, Lee YH, Kwon BS, Choi HS. Recombinant glucocorticoid induced tumor necrosis factor receptor (rGITR) induces NOS in murine macrophage FEBS Lett. 2002 Mar 13;514(2-3):275-80._x000D_ 8: Ko HJ, Kim YJ, Kim YS, Chang WS, Ko SY, Chang SY, Sakaguchi S, Kang CY. A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model Cancer Res. 2007 Aug 1;67(15):7477-86._x000D_ 9: Shen P, Su Z, Wang S, Xu H. [Bioinformatic analysis of mouse glucocorticoid-induced tumor necrosis factor receptor-related protein] Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014 Nov;30(11):1205-8._x000D_ 10: Fromm G, de Silva S, Schreiber TH. Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists Front Immunol. 2023 Sep 19;14:1236332. _x000D_ _x000D_ Products Related to GITR Extracellular Domain (human, recombinant) can be found at Proteins

• Short Description:

  Catalog Number: B2017354 (100 µg)_x000D_ GITR (Glucocorticoid-Induced TNFR-Related protein) is a member of the tumor necrosis factor receptor (TNFR) superfamily. The extracellular domain of GITR is the portion of the protein that is located outside the cell and is involved in binding to its ligands. Recombinant GITR extracellular domain can be used to study protein-protein interactions, and drug development. The recombinant form ensures a consistent and pure supply of the protein for experimental purposes. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3