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AMD rabbit pAb

CAT: 0855-ES11246-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11246-02Size:100 µL
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Background
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Description
This gene encodes a multifunctional protein. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase (PHM) domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain. These catalytic domains work sequentially to catalyze the conversion of neuroendocrine peptides to active alpha-amidated products. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016],
UniProt
P19021
Swiss Prot
P19021
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 380-460
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
107kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
107kD
Fragment
IgG
Subcellular Location
Cytoplasmic vesicle, secretory vesicle membrane ; Single-pass membrane protein . Secretory granules. .; [Isoform 1]: Membrane; Single-pass type I membrane protein.; [Isoform 2]: Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Secreted from secretory granules.; [Isoform 4]: Secreted. Secreted from secretory granules.
Gene ID (Human)
5066

UniProtKB · P19021

Peptidyl-glycine alpha-amidating monooxygenase

AMD_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19021
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PAM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PAM
EC number
—
Processing
Precursor
Secondary accessions
A6NMR0, A8K293, O43211, O95080, Q16252, Q16253, Q54A45, Q86U53, Q8WVC7, Q9UCG0
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumCopperMetal-bindingVitamin CZinc

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoproteinSulfation

Cellular component

Cytoplasmic vesicleMembraneSecreted

Biological process

Lipid metabolism

Molecular function

LyaseMonooxygenaseMultifunctional enzymeOxidoreductase

Technical term

Proteomics identificationReference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix

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