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TNR21 rabbit pAb

CAT: 0855-ES11239-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11239-01Size:50 µL
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Background
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Description
This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013],
UniProt
O75509
Swiss Prot
O75509
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 430-510
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
72kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
72kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein .
Gene ID (Human)
27242

UniProtKB · O75509

Tumor necrosis factor receptor superfamily member 21

TNR21_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75509
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNFRSF21
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2RDI9, Q0D2P5, Q96D86
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityApoptosisHost-virus interactionImmunity

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinLipoproteinOxidationPalmitate

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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