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DNER rabbit pAb

CAT: 0855-ES11005-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES11005-02Size:100 µL
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Background
Function:Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis., similarity:Contains 1 follistatin-like domain., similarity:Contains 10 EGF-like domains., subcellular location:Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region., subunit:Interacts with AP1G1. Interacts with NOTCH1., tissue specificity:Expressed in brain, spinal cord and adrenal gland.
Description
Function: Activator of the NOTCH1 pathway. May mediate neuron-glia interaction during astrocytogenesis. similarity: Contains 1 follistatin-like domain. similarity: Contains 10 EGF-like domains. subcellular location: Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region. subunit: Interacts with AP1G1. Interacts with NOTCH1. tissue specificity: Expressed in brain, spinal cord and adrenal gland.
UniProt
Q8NFT8
Swiss Prot
Q8NFT8
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
81kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
81kD
Fragment
IgG
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Present on the membrane of dendrites and cell bodies but excluded from axonal membrane. Also found in early endosomes in the somatodendritic region (By similarity) . .
Gene ID (Human)
92737

UniProtKB · Q8NFT8

Delta and Notch-like epidermal growth factor-related receptor

DNER_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NFT8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DNER
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A6NP39, Q53R88, Q53TP7, Q53TQ5, Q8IYT0, Q8TB42, Q9NTF1, Q9UDM2
Protein keywords

Molecular function

ActivatorReceptor

Ligand

Calcium

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Biological process

Notch signaling pathway

Technical term

Proteomics identificationReference proteome

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