UVRAG rabbit pAb

• Background:

  This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI (3) KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008]

• Description:

  This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI (3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer. [provided by RefSeq, Jul 2008],

• UniProt:

  Q9P2Y5

• Swiss Prot:

  Q9P2Y5

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from part region of human protein. AA range 655-675

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  76kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  76kD

• Fragment:

  IgG

• Subcellular Location:

  Late endosome . Lysosome . Cytoplasmic vesicle, autophagosome . Early endosome . Endoplasmic reticulum . Midbody . Chromosome, centromere . Colocalizes with RAB9-positive compartments involved in retrograde transport from late endosomes to trans-Golgi network. Colocalization with early endosomes is only partial (PubMed:24056303) . Recruited to autophagosome following interaction with RUBCNL/PACER (PubMed:28306502) . .

• Gene ID (Human):

  7405