NFE2 rabbit pAb

• Background :

  Function:Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron., similarity:Belongs to the bZIP family., similarity:Belongs to the bZIP family. CNC subfamily., similarity:Contains 1 bZIP domain., subunit:Interacts with MLL2; leading to activate transcription of the beta-globin locus (By similarity) . Heterodimer of p45 NF-E2 and p18 NF-E2. Forms high affinity heterodimer with MAFG; the interaction promotes erythropoiesis., tissue specificity:Expressed in hematopoietic cells and also in colon and testis.

• Description :

  Function: Required for activity at the locus control region (LCR) upstream of the globin gene complexes. Requires p18 NF-E2 for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production: globin synthesis, heme synthesis, and the procurement of iron. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. CNC subfamily. similarity: Contains 1 bZIP domain. subunit: Interacts with MLL2; leading to activate transcription of the beta-globin locus (By similarity). Heterodimer of p45 NF-E2 and p18 NF-E2. Forms high affinity heterodimer with MAFG; the interaction promotes erythropoiesis. tissue specificity: Expressed in hematopoietic cells and also in colon and testis.

• UniProt :

  Q16621

• Swiss Prot :

  Q16621

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  NFE2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  41kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  41kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus, PML body. Cytoplasm. The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs) . Translocated to the cytoplasm through interaction with ITCH.

• Gene ID (Human) :

  4778