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C11B2 rabbit pAb

CAT: 0855-ES10675-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10675-02Size:100 µL
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Background
Cytochrome P450 family 11 subfamily B member 2 (CYP11B2) Homo sapiens This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
Description
Cytochrome P450 family 11 subfamily B member 2 (CYP11B2) Homo sapiens This gene encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008],
UniProt
P19099
Swiss Prot
P19099
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human protein . at AA range: 280-360
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
55kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
55kD
Fragment
IgG
Subcellular Location
Mitochondrion inner membrane ; Peripheral membrane protein .
Gene ID (Human)
1585

UniProtKB · P19099

Cytochrome P450 11B2, mitochondrial

C11B2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19099
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CYP11B2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B0ZBE4, Q16726
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Disease

Disease variant

Ligand

HemeIronMetal-binding

Biological process

Lipid metabolismSteroid metabolismSteroidogenesis

Cellular component

MembraneMitochondrionMitochondrion inner membrane

Molecular function

MonooxygenaseOxidoreductase

Domain

Transit peptide

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