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DDB2 rabbit pAb

CAT: 0855-ES10618-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES10618-02Size:100 µL
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Background
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Description
This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014],
UniProt
Q92466
Swiss Prot
Q92466
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 260-340
Target
DDB2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
-20°C/1 year
Molecular Weight
46kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
46kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Accumulates at sites of DNA damage following UV irradiation. .
Gene ID (Human)
1643

UniProtKB · Q92466

DNA damage-binding protein 2

DDB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92466
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DDB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R875, Q76E54, Q76E55, Q76E56, Q76E57
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Cellular component

ChromosomeNucleus

Disease

Disease variantXeroderma pigmentosum

Biological process

DNA damageDNA repairUbl conjugation pathway

Molecular function

DNA-binding

Domain

RepeatWD repeat

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