ASPM rabbit pAb

• Description:

  This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011],

• Gene ID:

  259266

• UniProt:

  Q8IZT6

• Cellular Locus:

  Cytoplasm. Cytoplasm, cytoskeleton, spindle. Nucleus. The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity). Localizes to spindle poles during mitosis (PubMed:19690332). Associates with microtubule minus ends (By similarity)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Rat, Mouse,

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 1230-1310

• Clonality:

  Polyclonal

• Validated Applications:

  IHC, IF

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  IHC-p 1:50-300

• Molecular Weight:

  382kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.