ASPM rabbit pAb

• Background:

  This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

• Description:

  This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011],

• UniProt:

  Q8IZT6

• Swiss Prot:

  Q8IZT6

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 1230-1310

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IHC; IF

• Concentration:

  1 mg/ml

• Dilution:

  IHC-p 1:50-300

• Molecular Weight:

  382kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  382kD

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity) . Localizes to spindle poles during mitosis (PubMed:19690332) . Associates with microtubule minus ends (By similarity) . .

• Gene ID (Human):

  259266