ASPM rabbit pAb

CAT: 0855-ES10611-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES10611-01Size:50 µL
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Background
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Description
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011],
UniProt
Q8IZT6
Swiss Prot
Q8IZT6
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 1230-1310
Target
ASPM
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
382kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
382kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton, spindle . Nucleus . The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin (By similarity) . Localizes to spindle poles during mitosis (PubMed:19690332) . Associates with microtubule minus ends (By similarity) . .
Gene ID (Human)
259266

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