SCN1B rabbit pAb

SCN1B rabbit pAb

• Description: Voltage-gated sodium channels are heteromeric proteins that function in the generation and propagation of action potentials in muscle and neuronal cells. They are composed of one alpha and two beta subunits, where the alpha subunit provides channel activity and the beta-1 subunit modulates the kinetics of channel inactivation. This gene encodes a sodium channel beta-1 subunit. Mutations in this gene result in generalized epilepsy with febrile seizures plus, Brugada syndrome 5, and defects in cardiac conduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009],
• Gene ID: 6324
• UniProt: Q07699
• Cellular Locus: [Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Perikaryon. Cell projection. Cell projection, axon. Detected at nodes of Ranvier on the sciatic nerve..; [Isoform 2]: Perikaryon. Cell projection. Secreted. Detected on Purkinje cells and their cell projections and on neuronal cell projections..
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse
• Immunogen: Synthesized peptide derived from part region of human protein
• Clonality: Polyclonal
• Validated Applications: WB, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000 ELISA 1:5000-20000
• Molecular Weight: 23kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.