PPIG rabbit pAb

• Background:

  Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0) ., domain:The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II., enzyme regulation:Cyclosporin A (CsA) -sensitive., function:PPIases accelerate the folding of proteins., function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the cyclophilin-type PPIase family., similarity:Contains 1 PPIase cyclophilin-type domain., subcellular location:Colocalizes with RNA splicing factors at nuclear speckles., subunit:Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II., tissue specificity:Ubiquitous.

• Description:

  Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0). Domain: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II. enzyme regulation: Cyclosporin A (CsA)-sensitive. function: PPIases accelerate the folding of proteins. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the cyclophilin-type PPIase family. similarity: Contains 1 PPIase cyclophilin-type domain. subcellular location: Colocalizes with RNA splicing factors at nuclear speckles. subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II. tissue specificity: Ubiquitous.

• UniProt:

  Q13427

• Swiss Prot:

  Q13427

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  Synthesized peptide derived from human protein . at AA range: 290-370

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight:

  82kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  82kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus matrix . Nucleus speckle . Colocalizes with RNA splicing factors at nuclear speckles. .

• Gene ID (Human):

  9360