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PPIG rabbit pAb

CAT: 0855-ES9975-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9975-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0) ., domain:The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II., enzyme regulation:Cyclosporin A (CsA) -sensitive., function:PPIases accelerate the folding of proteins., function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the cyclophilin-type PPIase family., similarity:Contains 1 PPIase cyclophilin-type domain., subcellular location:Colocalizes with RNA splicing factors at nuclear speckles., subunit:Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II., tissue specificity:Ubiquitous.
Description
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0). Domain: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II. enzyme regulation: Cyclosporin A (CsA)-sensitive. function: PPIases accelerate the folding of proteins. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the cyclophilin-type PPIase family. similarity: Contains 1 PPIase cyclophilin-type domain. subcellular location: Colocalizes with RNA splicing factors at nuclear speckles. subunit: Interacts with CLK1, PNN and with the phosphorylated C-terminal domain of RNA polymerase II. tissue specificity: Ubiquitous.
UniProt
Q13427
Swiss Prot
Q13427
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 290-370
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
82kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
82kD
Fragment
IgG
Subcellular Location
Nucleus matrix . Nucleus speckle . Colocalizes with RNA splicing factors at nuclear speckles. .
Gene ID (Human)
9360