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MAML2 rabbit pAb

CAT: 0855-ES9783-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES9783-02Size:100 µL
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Background
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL) . Copy number variation in the p
Description
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the p
UniProt
Q8IZL2
Swiss Prot
Q8IZL2
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 10-90
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
127kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
127kD
Fragment
IgG
Subcellular Location
Nucleus speckle . Nuclear, in a punctate manner.
Gene ID (Human)
84441

UniProtKB · Q8IZL2

Mastermind-like protein 2

MAML2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8IZL2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAML2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Mam-2
EC number
—
Processing
—
Secondary accessions
A7MD26, Q6AI23, Q6Y3A3, Q8IUL3, Q96JK6
Protein keywords

Molecular function

Activator

Coding sequence diversity

Chromosomal rearrangement

Biological process

Notch signaling pathwayTranscriptionTranscription regulation

Cellular component

Nucleus

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

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