Products for Research Use Only
RegisterLogin

IBTK rabbit pAb

CAT: 0855-ES9099-02Size: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES9099-02Size:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
Description
Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014],
UniProt
Q9P2D0
Swiss Prot
Q9P2D0
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human protein . at AA range: 410-490
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Molecular Weight
148kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
148kD
Fragment
IgG
Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein. Translocates to the plasma membrane upon IgM stimulation.; [Isoform 2]: Nucleus.
Gene ID (Human)
25998

UniProtKB · Q9P2D0

Inhibitor of Bruton tyrosine kinase

IBTK_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9P2D0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IBTK
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IBtk
EC number
—
Processing
—
Secondary accessions
Q2QKU2, Q2QKU3, Q2QKU4, Q5TFD7, Q5TFD9, Q8IUQ9, Q8IUY7, Q8TAI4, Q9HBI8, Q9Y3T8
Protein keywords

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Cellular component

CytoplasmMembraneNucleus

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Related Products

CatalogName
ES4666-01RAB3IP rabbit pAb
ES20659-01NBR1 Rabbit rabbit pAb
ES20825-01ATG7 Rabbit rabbit pAb
ES20831-01ATG13 Rabbit rabbit pAb
ES20599-01VEGF Rabbit rabbit pAb
ES20596-01WIPI2 Rabbit rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb

Alternative Products

CatalogName
E45R21418N-50IBTK Rabbit pAb
MBS9514930-01IBTK Rabbit Polyclonal Antibody
GB114533-100Anti-IBTK Rabbit pAb
NBP1-88512Rabbit Polyclonal IBTK Antibody
SL15532R-01Rabbit Anti-IBTK antibody
APR21418N-01IBTK Rabbit pAb (APR21418N)
GTR17712772IBTK Rabbit Polyclonal Antibody (HRP)
GTR17735060IBTK Rabbit Polyclonal Antibody (Biotin)
CSB-CL882177HUIBTK

Popular Products