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ACO2 rabbit pAb

CAT: 0855-ES8872-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8872-02Size:100 µL
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Background
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15 (PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15 (PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008],
UniProt
Q99798
Swiss Prot
Q99798
Reactivity
Human; Mouse; Rat; Canine
Immunogen
Synthesized peptide derived from human ACO2. at AA range: 421-470
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000.Not yet tested in other applications.
Molecular Weight
90kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
90kD
Fragment
IgG
Subcellular Location
Mitochondrion .
Other Product Names
Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)
Gene ID (Human)
50

UniProtKB · Q99798

Aconitate hydratase, mitochondrial

ACON_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99798
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACO2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Aconitase
EC number
4.2.1.3
Processing
Precursor
Secondary accessions
O75809, Q5JZ41, Q6FHX0, Q8TAQ6
Protein keywords

Ligand

4Fe-4SIronIron-sulfurMetal-binding

PTM

AcetylationPhosphoprotein

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantNeurodegeneration

Molecular function

Lyase

Cellular component

Mitochondrion

Domain

Transit peptide

Biological process

Tricarboxylic acid cycle

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