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PBEF rabbit pAb

CAT: 0855-ES8855-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8855-02Size:100 µL
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Background
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011]
Description
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011],
Product Name Alternative
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)
UniProt
P43490
Swiss Prot
P43490
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human PBEF. at AA range: 411-460
Target
PBEF
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
54kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
54kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Secreted . Under non-inflammatory conditions, visfatin predominantly exhibits a granular pattern within the nucleus. Secreted by endothelial cells upon IL-1beta stimulation. Abundantly secreted in milk, reaching 100-fold higher concentrations compared to maternal serum. .
Other Product Names
Nicotinamide phosphoribosyltransferase (NAmPRTase) (Nampt) (EC 2.4.2.12) (Pre-B-cell colony-enhancing factor 1) (Pre-B cell-enhancing factor) (Visfatin)
Gene ID (Human)
10135

UniProtKB · P43490

Nicotinamide phosphoribosyltransferase

NAMPT_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43490
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NAMPT
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
NAmPRTase, Nampt
EC number
2.4.2.12
Processing
—
Secondary accessions
A4D0Q9, A4D0R0, Q3KQV0, Q8WW95
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Biological process

Biological rhythmsPyridine nucleotide biosynthesis

Molecular function

CytokineGlycosyltransferaseTransferase

Cellular component

CytoplasmNucleusSecreted

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