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C8 β rabbit pAb

CAT: 0855-ES8518-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8518-01Size:50 µL
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Background
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Description
This gene encodes one of the three subunits of the complement component 8 (C8) protein. C8 is composed of equimolar amounts of alpha, beta and gamma subunits, which are encoded by three separate genes. C8 is one component of the membrane attack complex, which mediates cell lysis, and it initiates membrane penetration of the complex. This protein mediates the interaction of C8 with the C5b-7 membrane attack complex precursor. In humans deficiency of this protein is associated with increased risk of meningococcal infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013],
Product Name Alternative
Complement component C8 beta chain (Complement component 8 subunit beta)
UniProt
P07358
Swiss Prot
P07358
Reactivity
Human; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human C8B. AA range:371-420
Target
C8 β
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000, ELISA 1:10000-20000
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Secreted.
Other Product Names
Complement component C8 beta chain (Complement component 8 subunit beta)
Gene ID (Human)
732

UniProtKB · P07358

Complement component C8 beta chain

CO8B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P07358
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
C8B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A1L4K7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Complement alternate pathwayComplement pathwayCytolysisImmunityInnate immunity

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane beta strand

Cellular component

MembraneMembrane attack complexSecretedTarget cell membraneTarget membrane

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