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DZIP3 rabbit pAb

CAT: 0855-ES8083-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES8083-02Size:100 µL
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Background
Function:E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA., pathway:Protein modification; protein ubiquitination., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Contains 1 RING-type zinc finger., subunit:Interacts with DAZ proteins., tissue specificity:Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
Description
Function: E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. pathway: Protein modification; protein ubiquitination. sequence Caution: Contaminating sequence. Potential poly-A sequence. similarity: Contains 1 RING-type zinc finger. subunit: Interacts with DAZ proteins. tissue specificity: Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.
UniProt
Q86Y13
Swiss Prot
Q86Y13
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DZIP3. AA range:681-730
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
140kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
140kD
Fragment
IgG
Subcellular Location
Cytoplasm .
Other Product Names
DZIP3; KIAA0675; E3 ubiquitin-protein ligase DZIP3; DAZ-interacting protein 3; RNA-binding ubiquitin ligase of 138 kDa; hRUL138
Gene ID (Human)
9666

UniProtKB · Q86Y13

E3 ubiquitin-protein ligase DZIP3

DZIP3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q86Y13
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DZIP3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.2.27
Processing
—
Secondary accessions
B3KN01, O75162, Q6P3R9, Q6PH82, Q86Y14, Q86Y15, Q86Y16, Q8IWI0, Q96RS9
Protein keywords

Coding sequence diversity

Alternative splicing

Domain

Coiled coilZinc-finger

Cellular component

Cytoplasm

Ligand

Metal-bindingZinc

Technical term

Proteomics identificationReference proteome

Molecular function

RNA-bindingTransferase

Biological process

Ubl conjugation pathway

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