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Dyrk1B rabbit pAb

CAT: 0855-ES7970-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7970-01Size:50 µL
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Background
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Description
This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
UniProt
Q9Y463
Swiss Prot
Q9Y463
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human DYR1B. AA range:331-380
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of double-strand breaks (DSBs) following DNA damage. .
Other Product Names
DYRK1B; MIRK; Dual specificity tyrosine-phosphorylation-regulated kinase 1B; Minibrain-related kinase; Mirk protein kinase
Gene ID (Human)
9149

UniProtKB · Q9Y463

Dual specificity tyrosine-phosphorylation-regulated kinase 1B

DYR1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y463
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DYRK1B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.12.1
Processing
—
Secondary accessions
O75258, O75788, O75789
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

ChromosomeNucleus

Disease

Diabetes mellitusObesity

Biological process

DNA damageDNA repair

Molecular function

KinaseSerine/threonine-protein kinaseTransferaseTyrosine-protein kinase

PTM

Phosphoprotein

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