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BinCARD rabbit pAb

CAT: 0855-ES7746-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7746-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner., PTM:Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 CARD domain., subcellular location:Co-expression with BCL10 induced translocation from nucleus to cytosol., subunit:Associates with BCL10 by CARD-CARD interaction., tissue specificity:Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level) . Expressed in thymus and brain.
Description
Function: Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. PTM: Isoform 2 is phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 CARD domain. subcellular location: Co-expression with BCL10 induced translocation from nucleus to cytosol. subunit: Associates with BCL10 by CARD-CARD interaction. tissue specificity: Expressed in ovary, testis, placenta, skeletal muscle, kidney, lung, heart and liver (at protein level). Expressed in thymus and brain.
UniProt
Q96LW7
Swiss Prot
Q96LW7
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human C9orf89. AA range:21-70
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
[Isoform 1]: Nucleus . Coexpression with BCL10 induced translocation from nucleus to cytosol.; [Isoform 2]: Endoplasmic reticulum membrane ; Single-pass membrane protein . Mitochondrion membrane ; Single-pass membrane protein .
Other Product Names
C9orf89; Bcl10-interacting CARD protein; BinCARD
Gene ID (Human)
84270

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