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Claudin-5 rabbit pAb

CAT: 0855-ES7401-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7401-01Size:50 µL
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Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008]
Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Mutations in this gene have been found in patients with velocardiofacial syndrome. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2008],
UniProt
O00501
Swiss Prot
O00501
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 5. AA range:169-218
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
23kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
23kD
Fragment
IgG
Subcellular Location
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Other Product Names
CLDN5; AWAL; TMVCF; Claudin-5; Transmembrane protein deleted in VCFS; TMDVCF
Gene ID (Human)
7122

UniProtKB · O00501

Claudin-5

CLD5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O00501
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLDN5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B3KS11, Q53XW2, Q8WUW3
Protein keywords

Cellular component

Cell junctionCell membraneMembraneTight junction

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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