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Claudin-19 rabbit pAb

CAT: 0855-ES1986-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1986-01Size:50 µL
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Background
The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO) . HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010]
Description
The product of this gene belongs to the claudin family. It plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Defects in this gene are the cause of hypomagnesemia renal with ocular involvement (HOMGO). HOMGO is a progressive renal disease characterized by primary renal magnesium wasting with hypomagnesemia, hypercalciuria and nephrocalcinosis associated with severe ocular abnormalities such as bilateral chorioretinal scars, macular colobomata, significant myopia and nystagmus. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010],
Product Name Alternative
CLDN19; Claudin-19
UniProt
Q8N6F1
Swiss Prot
Q8N6F1
Reactivity
Human; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human CLDN19. AA range:81-130
Target
Claudin-19
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
23kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
23kD
Fragment
IgG
Subcellular Location
Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
Other Product Names
CLDN19; Claudin-19
Gene ID (Human)
149461

UniProtKB · Q8N6F1

Claudin-19

CLD19_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N6F1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLDN19
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B7Z5I2, F5H5P9, Q5QT57, Q8N8X0
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCell membraneMembraneTight junction

Disease

Disease variantPrimary hypomagnesemia

PTM

Disulfide bond

Ligand

Magnesium

Technical term

Proteomics identificationReference proteome

Biological process

Sensory transductionVision

Domain

TransmembraneTransmembrane helix

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