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Claudin-6 rabbit pAb

CAT: 0855-ES1990-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1990-01Size:50 µL
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Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.[provided by RefSeq, Aug 2010]
Description
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16. [provided by RefSeq, Aug 2010],
Product Name Alternative
CLDN6; Claudin-6; Skullin
UniProt
P56747
Swiss Prot
P56747
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CLDN6. AA range:81-130
Target
Claudin-6
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
26kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
26kD
Fragment
IgG
Subcellular Location
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
Other Product Names
CLDN6; Claudin-6; Skullin
Gene ID (Human)
9074

UniProtKB · P56747

Claudin-6

CLD6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P56747
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLDN6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B3KQP9, D3DUA5
Protein keywords

Cellular component

Cell junctionCell membraneMembraneTight junction

Molecular function

Host cell receptor for virus entryReceptor

Biological process

Host-virus interaction

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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