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Claudin-11 rabbit pAb

CAT: 0855-ES6450-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
Description
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different iso
Product Name Alternative
CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein
UniProt
O75508
Swiss Prot
O75508
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 11. AA range:158-207
Target
Claudin 11
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
20kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
20kD
Fragment
IgG
Subcellular Location
Cell junction, tight junction. Cell membrane ; Multi-pass membrane protein .
Other Product Names
CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein
Gene ID (Human)
5010

UniProtKB · O75508

Claudin-11

CLD11_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75508
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLDN11
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R7C1, D3DNQ5, Q5U0P3
Protein keywords

Cellular component

Cell junctionCell membraneMembraneTight junction

Disease

Leukodystrophy

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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