Nicalin rabbit pAb

• Background:

  Function:May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning., similarity:Belongs to the nicastrin family., subunit:Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex., tissue specificity:Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.

• Description:

  Function: May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. similarity: Belongs to the nicastrin family. subunit: Interacts with NOMO2. Due to the strong similarity between NOMO1, NOMO2 and NOMO3, it probably also interacts with NOMO1 and NOMO3. Participates in a large protein complex, which is not related to the gamma-secretase complex. tissue specificity: Highly expressed in pancreas and skeletal muscle and, at lower levels, in heart.

• Synonyms:

  NCLN; Nicalin; Nicastrin-like protein

• Gene ID:

  56926

• UniProt:

  Q969V3

• Cellular Locus:

  Endoplasmic reticulum membrane ; Single-pass membrane protein.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human NCLN. AA range:474-523

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  63kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  63 kD

• Subcellular Location:

  Endoplasmic reticulum membrane ; Single-pass membrane protein .

• Other Product Names:

  NCLN; Nicalin; Nicastrin-like protein

• Gene ID (Human):

  56926

• SwissProt (Human):

  Q969V3