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S2P rabbit pAb

CAT: 0855-ES6518-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6518-01Size:50 µL
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Background
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome) ; IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.[provided by RefSeq, Aug 2009]
Description
This gene encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response. [provided by RefSeq, Aug 2009],
UniProt
O43462
Swiss Prot
O43462
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MBTPS2. AA range:301-350
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IP; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Membrane ; Multi-pass membrane protein . Cytoplasm .
Other Product Names
MBTPS2; S2P; Membrane-bound transcription factor site-2 protease; Endopeptidase S2P; Sterol regulatory element-binding proteins intramembrane protease; SREBPs intramembrane protease
Gene ID (Human)
51360

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