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Somatotropin rabbit pAb

CAT: 0855-ES5517-01Size: 50 µLDry Ice: NoHazardous: No
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Background
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008],
UniProt
P01241
Swiss Prot
P01241
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Somatotropin.
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Secreted.
Other Product Names
GH1; Somatotropin; Growth hormone; GH; GH-N; Growth hormone 1; Pituitary growth hormone
Gene ID (Human)
2688

UniProtKB · P01241

Somatotropin

SOMA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01241
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A6NEF6, Q14405, Q16631, Q5EB53, Q9HBZ1, Q9UMJ7, Q9UNL5
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantDwarfism

PTM

Disulfide bondPhosphoprotein

Molecular function

Hormone

Ligand

Metal-bindingZinc

Cellular component

Secreted

Domain

Signal

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