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DGK-β rabbit pAb

CAT: 0855-ES4958-02Size: 100 µLDry Ice: NoHazardous: No
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Background
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD) . The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Description
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008],
Product Name Alternative
DGKB; DAGK2; KIAA0718; Diacylglycerol kinase beta; DAG kinase beta; 90 kDa diacylglycerol kinase; Diglyceride kinase beta; DGK-beta
UniProt
Q9Y6T7
Swiss Prot
Q9Y6T7
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human DGKB. AA range:657-706
Target
DGK-β
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
90kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
90kD
Fragment
IgG
Subcellular Location
Cell junction, synapse, postsynaptic cell membrane ; Peripheral membrane protein . Cell membrane ; Peripheral membrane protein . Cytoplasm . Translocation to the plasma membrane is induced by phorbol esters. .; [Isoform 2]: Cytoplasm .
Other Product Names
DGKB; DAGK2; KIAA0718; Diacylglycerol kinase beta; DAG kinase beta; 90 kDa diacylglycerol kinase; Diglyceride kinase beta; DGK-beta
Gene ID (Human)
1607

UniProtKB · Q9Y6T7

Diacylglycerol kinase beta

DGKB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9Y6T7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DGKB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
DAG kinase beta
EC number
2.7.1.107
Processing
—
Secondary accessions
A4D116, A4D117, A8MXU2, O75241, Q2M377, Q75MF9, Q75MU7, Q86UI5, Q86UM9, Q9UQ29
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingZinc

Cellular component

Cell membraneCytoplasmMembranePostsynaptic cell membraneSynapse

Molecular function

KinaseTransferase

Biological process

Lipid metabolism

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Domain

RepeatZinc-finger