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CD85d rabbit pAb

CAT: 0855-ES4325-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4325-02Size:100 µL
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Background
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) . The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Description
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13. 4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Product Name Alternative
LILRB2; ILT4; LIR2; MIR10; Leukocyte immunoglobulin-like receptor subfamily B member 2; LIR-2; Leukocyte immunoglobulin-like receptor 2; CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d
UniProt
Q8N423
Swiss Prot
Q8N423
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human LILRB2. AA range:121-170
Target
CD85d
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
66kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
66kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein.
Other Product Names
LILRB2; ILT4; LIR2; MIR10; Leukocyte immunoglobulin-like receptor subfamily B member 2; LIR-2; Leukocyte immunoglobulin-like receptor 2; CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d
Gene ID (Human)
10288

UniProtKB · Q8N423

Leukocyte immunoglobulin-like receptor subfamily B member 2

LIRB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N423
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LILRB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
LIR-2, Leukocyte immunoglobulin-like receptor 2
EC number
—
Processing
Precursor
Secondary accessions
A2IXV5, A8MU67, C9JF29, O75017, Q8NHJ7, Q8NHJ8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative initiationAlternative promoter usageAlternative splicing

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

Receptor

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