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CD177 rabbit pAb

CAT: 0855-ES4013-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4013-02Size:100 µL
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Background
This gene encodes a glycosyl-phosphatidylinositol (GPI) -linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Description
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014],
Product Name Alternative
CD177; NB1; PRV1; CD177 antigen; Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD177
UniProt
Q8N6Q3
Swiss Prot
Q8N6Q3
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human CD177. AA range:361-410
Target
CD177
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
46kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
46kD
Fragment
IgG
Subcellular Location
Cell membrane ; Lipid-anchor, GPI-anchor . Membrane raft ; Lipid-anchor, GPI-like-anchor . Secreted . Cytoplasmic granule membrane . Cell projection, lamellipodium . Cell surface expression on neutrophils is increased upon TNF-alpha, fMLP or CXCL8/IL8-mediated stimulation (PubMed:17244676, PubMed:17580308) . In neutrophils, stored predominantly in secondary and tertiary granules (PubMed:18462208) . Can also be shedded from the cell membrane (PubMed:12239154, PubMed:18462208) . Localizes to lamellar protrusions in spreading neutrophils (PubMed:28807980) . .
Other Product Names
CD177; NB1; PRV1; CD177 antigen; Human neutrophil alloantigen 2a; HNA-2a; NB1 glycoprotein; NB1 GP; Polycythemia rubra vera protein 1; PRV-1; CD177
Gene ID (Human)
57126

UniProtKB · Q8N6Q3

CD177 antigen

CD177_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8N6Q3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CD177
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q711Q2, Q8NCV9, Q96QH1, Q9HDA5
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesionImmunityInnate immunity

Cellular component

Cell membraneCell projectionMembraneSecreted

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

GlycoproteinGPI-anchorLipoprotein

Domain

RepeatSignal

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