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MLH1 rabbit pAb

CAT: 0855-ES2797-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2797-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.[provided by RefSeq, Nov 2009]
Description
This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. [provided by RefSeq, Nov 2009],
Product Name Alternative
MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1
UniProt
P40692
Swiss Prot
P40692
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human MLH1. AA range:441-490
Target
MLH1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Buffer
-20°C/1 year
Molecular Weight
85kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
85kD
Fragment
IgG
Subcellular Location
Nucleus . Chromosome . Recruited to chromatin in a MCM9-dependent manner. .
Other Product Names
MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1
Gene ID (Human)
4292

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