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LRRC41 rabbit pAb

CAT: 0855-ES2726-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES2726-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Caution:It is uncertain whether Met-1 or Met-23 is the initiator., domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x (3) -C-x (3) -[AILV]., function:Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., pathway:Protein modification; protein ubiquitination., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Translation N-terminally extended., similarity:Contains 7 LRR (leucine-rich) repeats., subunit:Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS (LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.
Description
Caution: It is uncertain whether Met-1 or Met-23 is the initiator. Domain: The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x (3)-C-x (3)-[AILV]. function: Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. pathway: Protein modification; protein ubiquitination. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. sequence Caution: Translation N-terminally extended. similarity: Contains 7 LRR (leucine-rich) repeats. subunit: Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS (LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.
UniProt
Q15345
Swiss Prot
Q15345
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human LRRC41. AA range:391-440
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
80kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
80kD
Fragment
IgG
Subcellular Location
Nucleus, cytoplasm, membrane
Other Product Names
LRRC41; MUF1; PP7759; Leucine-rich repeat-containing protein 41; Protein Muf1
Gene ID (Human)
10489

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