HBO1 rabbit pAb

Catalytic activity:Acetyl-CoA + histone = CoA + acetylhistone., domain:The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L., domain:The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction., function:Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the MYST (SAS/MOZ) family., similarity:Contains 1 C2HC-type zinc finger., subunit:Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone., tissue specificity:Ubiquitously expressed, with highest levels in testis.

Catalytic activity: Acetyl-CoA + histone = CoA + acetylhistone. Domain: The C2HC-type zinc finger is required for interaction with MCM2 and ORC1L. Domain: The N-terminus is involved in transcriptional repression, while the C-terminus mediates AR-interaction. function: Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the MYST (SAS/MOZ) family. similarity: Contains 1 C2HC-type zinc finger. subunit: Component of the HBO1 complex composed at least of ING4 or ING5, MYTS2/HBO1, EAF6, and one of PHF15, PHF16 and PHF17. Interacts with MCM2 and ORC1L. Interacts with the androgen receptor (AR) in the presence of dihydrotestosterone. tissue specificity: Ubiquitously expressed, with highest levels in testis.

KAT7; HBO1; HBOa; MYST2; Histone acetyltransferase KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ; YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2

O95251

O95251

Human; Mouse; Rat

The antiserum was produced against synthesized peptide derived from human MYST2. AA range:131-180

HBO1

Rabbit

WB; IF; ELISA

1 mg/ml

Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

-20°C/1 year

75kD

-20°C/1 year

75kD

IgG

Nucleus . Chromosome . Chromosome, centromere . Cytoplasm, cytosol . Associates with replication origins specifically during the G1 phase of the cell cycle (PubMed:18832067, PubMed:20129055) . Localizes to transcription start sites (PubMed:21753189, PubMed:24065767) . Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR (PubMed:28719581) . Localizes to centromeres in G1 phase (PubMed:27270040) . .

KAT7; HBO1; HBOa; MYST2; Histone acetyltransferase KAT7; Histone acetyltransferase binding to ORC1; Lysine acetyltransferase 7; MOZ; YBF2/SAS3, SAS2 and TIP60 protein 2; MYST-2