Dbf4 rabbit pAb

CAT: 0855-ES2148-02Size: 100 µLDry Ice: NoHazardous: No

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CAT#:0855-ES2148-02Size:100 µL

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Background

Function:Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle., induction:Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Contains 1 DBF4-type zinc finger., similarity:Contains 2 BRCT domains., subunit:Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2L, ORC4L and ORC6L., tissue specificity:Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

Description

Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. induction: Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Contains 1 DBF4-type zinc finger. similarity: Contains 2 BRCT domains. subunit: Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2L, ORC4L and ORC6L. tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

UniProt

Q9UBU7

Swiss Prot

Q9UBU7

Reactivity

Human; Mouse; Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human DBF4. AA range:10-59

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Molecular Weight

77kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

77kD

Fragment

IgG

Subcellular Location

Nucleus .

Other Product Names

DBF4; ASK; DBF4A; ZDBF1; Protein DBF4 homolog A; Activator of S phase kinase; Chiffon homolog A; DBF4-type zinc finger-containing protein 1

Gene ID (Human)

10926

UniProtKB · Q9UBU7

Protein DBF4 homolog A

DBF4A_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9UBU7
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: DBF4
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A4D1D8, A8K954, O75226, Q75MS6, Q75N01, Q9Y2M6

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell cycleDNA replication

Ligand

Metal-bindingZinc

Cellular component

Nucleus

PTM

Phosphoprotein

Domain

RepeatZinc-finger

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