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Claudin-1 rabbit pAb

CAT: 0855-ES1985-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES1985-01Size:50 µL
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Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008]
Description
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. [provided by RefSeq, Jul 2008],
Product Name Alternative
CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
UniProt
O95832
Swiss Prot
O95832
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Claudin 1. AA range:162-211
Target
Claudin 1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
22kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
22kD
Fragment
IgG
Subcellular Location
Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane . Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. .
Other Product Names
CLDN1; CLD1; SEMP1; Claudin-1; Senescence-associated epithelial membrane protein
Gene ID (Human)
9076

UniProtKB · O95832

Claudin-1

CLD1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O95832
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CLDN1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Cellular component

Cell junctionCell membraneMembraneTight junction

PTM

Disulfide bond

Molecular function

Host cell receptor for virus entryReceptor

Biological process

Host-virus interaction

Disease

Ichthyosis

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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