Products for Research Use Only

JAK2 (phospho Tyr1007) rabbit pAb

CAT: 0855-ES1348-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES1348-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]
Description
This gene product is a protein tyrosine kinase involved in a specific subset of Cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008],
Product Name Alternative
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
UniProt
O60674
Swiss Prot
O60674
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr1007. AA range:981-1030
Target
JAK2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130kD
Fragment
IgG
Subcellular Location
Endomembrane system ; Peripheral membrane protein . Cytoplasm . Nucleus .
Other Product Names
JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2
Gene ID (Human)
3717

UniProtKB · O60674

Tyrosine-protein kinase JAK2

JAK2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O60674
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
JAK2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.2
Processing
—
Secondary accessions
O14636, O75297
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Biological process

Adaptive immunityImmunityInnate immunity

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Molecular function

Chromatin regulatorKinaseTransferaseTyrosine-protein kinase

Coding sequence diversity

Chromosomal rearrangement

Cellular component

CytoplasmMembraneNucleus

Disease

Disease variantProto-oncogene

PTM

PhosphoproteinUbl conjugation

Domain

RepeatSH2 domain

Popular Products