JAK2 (phospho Tyr221) rabbit pAb

• Background:

  This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008]

• Description:

  This gene product is a protein tyrosine kinase involved in a specific subset of Cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. [provided by RefSeq, Jul 2008],

• Synonyms:

  JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

• Gene ID:

  3717

• UniProt:

  O60674

• Cellular Locus:

  Endomembrane system ; Peripheral membrane protein. Cytoplasm. Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human JAK2 around the phosphorylation site of Tyr221. AA range:191-240

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB, IHC, IF, ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C/1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

• Molecular Weight:

  130kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  130 kD

• Subcellular Location:

  Endomembrane system ; Peripheral membrane protein . Cytoplasm . Nucleus .

• Other Product Names:

  JAK2; Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2

• Gene ID (Human):

  3717

• SwissProt (Human):

  O60674