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GSK467

CAT: 0804-HY-116761-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116761-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK467 is a cell penetrant and selective KDM5B (JARID1B or PLU1) inhibitor with a Ki of 10 nM and an IC50 of 26 nM. GSK467 shows 180-fold selectivity for KDM4C and no measurable inhibitory effects toward KDM6 or other Jumonji family members[1][2].
CAS Number
1628332-52-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk467.html
Concentration
10mM
Purity
99.55
Solubility
DMSO : 20.83 mg/mL (ultrasonic)
Smiles
O=C1C2=C(NC(OC3=CN(N=C3)CC4=CC=CC=C4)=N1)C=NC=C2
Molecular Formula
C17H13N5O2
Molecular Weight
319.32
Precautions
H302, H315, H319, H335
References & Citations
[1]Johansson C, et al. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12 (7) :539-45.|[2]Fu YD, et al. Targeting histone demethylase KDM5B for cancer treatment. Eur J Med Chem. 2020 Dec 15;208:112760.|[3]Guo JC, et al. KDM5B promotes self-renewal of hepatocellular carcinoma cells through the microRNA-448-mediated YTHDF3/ITGA6 axis. J Cell Mol Med. 2021 Apr 7;25 (13) :5949–62.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM5

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DQC33252-01GSK467
A18807-100GSK467 100mg
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A18807-10GSK467 10mg
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A18807-1GSK467 1mg
A18807-5GSK467 5mg
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