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GSK963

CAT: 0804-HY-103028A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103028A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK963 is a chiral, highly potent and selective inhibitor of RIP1 kinase, with an IC50 of 29 nM. GSK963 is a selective and potent inhibitor of necroptosis in murine and human cells in vitro[1].
CAS Number
2049868-46-2
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/GSK963.html
Concentration
10mM
Purity
99.10
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CC(C)(C)C(N1N=CC[C@H]1C2=CC=CC=C2)=O
Molecular Formula
C14H18N2O
Molecular Weight
230.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Berger SB, et al. Characterization of GSK'963: a structurally distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015 Jul 27;1:15009.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

(S)-2,2-Dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
CAS Number2049868-46-2
PubChem CID122703613
IUPAC Name2,2-dimethyl-1-[(3S)-3-phenyl-3,4-dihydropyrazol-2-yl]propan-1-one
Molecular FormulaC14H18N2O
Molecular Weight230.31
XLogP2.1
Topological Polar Surface Area32.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity311
SMILES
CC(C)(C)C(=O)N1[C@@H](CC=N1)C2=CC=CC=C2
InChI
InChI=1S/C14H18N2O/c1-14(2,3)13(17)16-12(9-10-15-16)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3/t12-/m0/s1
InChIKey
NJQVSLWJBLPTMD-LBPRGKRZSA-N
Chemical Structure
2D Structure
2D structure of (S)-2,2-Dimethyl-1-(5-phenyl-4,5-dihydro-1H-pyrazol-1-yl)propan-1-one
CAS: 2049868-46-2
CID: 122703613
Formula: C14H18N2O
MW: 230.31
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight230.31
XLogP32.1
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass230.141913202
Monoisotopic Mass230.141913202
Topological Polar Surface Area32.7 Ų
Heavy Atom Count17
Formal Charge0
Complexity311
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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BUP04014-01GSK963
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