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GSK547

CAT: 0804-HY-114492-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114492-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK547 (GSK'547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIPK1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer[1].
CAS Number
2226735-55-1
Product Name Alternative
GSK'547
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gsk547.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
N#CC1=NC=NC(N2CCC(C(N3N=CC[C@H]3C4=CC(F)=CC(F)=C4)=O)CC2)=C1
Molecular Formula
C20H18F2N6O
Molecular Weight
396.39
Precautions
H315, H319, H320
References & Citations
[1]Wang W, et al. RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer. Cancer Cell. 2018 Nov 12;34 (5) :757-774.e7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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