Products for Research Use Only
RegisterLogin

GSK046

CAT: 0804-HY-136571-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-136571-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
GSK046 (iBET-BD2), a chemical probe, is a potent, selective and orally active BD2 bromodomain inhibitor of the BET proteins, with IC50s of 264 nM (BRD2 BD2), 98 nM (BRD3 BD2), 49 nM (BRD4 BD2) and 214 nM (BRDT BD2), respectively. GSK046 has immunomodulatory activity[1].
CAS Number
2474876-09-8
Product Name Alternative
IBET-BD2
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gsk046.html
Purity
99.65
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(O[C@H](C3=CC=CC=C3)C)=C(NC(C)=O)C(F)=C2
Molecular Formula
C23H27FN2O4
Molecular Weight
414.47
References & Citations
[1]Omer G, et, al. Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation. Science. 2020 Apr 24; 368 (6489) : 387-394.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2; BRD3; BRD4; BRDT

Related Products

CatalogName
HY-132230GSK040
HY-132232GSK097
HY-176709GSK147
HY-104021-01GSK840
HY-114492-01GSK547
HY-157294-01GSK866
HY-19540-01GSK864
HY-149761GSK023
HY-13500-01GSK343
HY-116605GSK926

Alternative Products

CatalogName
M24132-01GSK046
A22068-10GSK046 10mg
A22068-100GSK046 100mg
A22068-1GSK046 1mg
A22068-50GSK046 50mg
A22068-25GSK046 25mg
A22068-5GSK046 5mg
C14411-01GSK046 (iBET-BD2)

Popular Products