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CDK7-IN-27

CAT: 0804-HY-162416Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162416Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase[1].
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk7-in-27.html
Solubility
10 mM in DMSO
Smiles
CC(C1=C2N=C3N=C(N2N=C1)NCC4=CC=CC=C4OC[C@H](CCCC5(CN3)CCNCC5)O)C
Molecular Formula
C26H37N7O2
Molecular Weight
479.62
References & Citations
[1]Niu P, et al., Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors. J Med Chem. 2024 Apr 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK7

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