CDK7-IN-27

• Description:

  CDK7-IN-27 (Compound 37) is a selective inhibitor for cyclin-dependent kinase 7 (CDK7), with Ki of 3 nM. CDK7-IN-27 arrests the cell cycle at G0/G1 phase[1].

• UNSPSC:

  12352005

• Target:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk7-in-27.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C1=C2N=C3N=C(N2N=C1)NCC4=CC=CC=C4OC[C@H](CCCC5(CN3)CCNCC5)O)C

• Molecular Formula:

  C26H37N7O2

• Molecular Weight:

  479.62

• References & Citations:

  [1]Niu P, et al., Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors. J Med Chem. 2024 Apr 8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK2; CDK7