CDK9-IN-27

CAT: 0804-HY-155177Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155177Size:1 Each
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK9-IN-27 (Compound 6a) is a CDK9 inhibitor (IC50s: 0.424 μM) . CDK9-IN-27 induces apoptosis and cell cycle arrest at S stage. CDK9-IN-27 has cytotoxic action against HepG2, HCT-116 and MCF-7 cell lines, with IC50s of 10.31-40.34 μM. CDK9-IN-27 can be used for cancer research[1].
UNSPSC
12352005
Target
CDK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk9-in-27.html
Solubility
10 mM in DMSO
Smiles
ClC(C=C1)=CC=C1C(C(C(OCC)=O)=C(N)N2CC3=NC4=CC=CC=C4N3)=C(C#N)C2=O
Molecular Formula
C23H18ClN5O3
Molecular Weight
447.87
References & Citations
[1]Husseiny EM, et al. Aminopyridone-linked benzimidazoles: a fragment-based drug design for the development of CDK9 inhibitors. Future Med Chem. 2023 Aug 16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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