PF-5190457

• Description:

  PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36[1].

• Product Name Alternative:

  PF-05190457

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  GHSR

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/PF-5190457.html

• Concentration:

  10mM

• Purity:

  99.16

• Solubility:

  DMSO : 250 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

• Smiles:

  CC1=NC=NC (C2=CC (CC[C@H]3N4CC5 (CCN (C (CC6=CN7C=C (C) SC7=N6) =O) CC5) C4) =C3C=C2) =C1

• Molecular Formula:

  C29H32N6OS

• Molecular Weight:

  512.67

• Precautions:

  H315, H319

• References & Citations:

  [1]Bhattacharya SK, et al. Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate. ACS Med Chem Lett. 2014 Feb 24;5 (5) :474-9.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  1334782-79-4