CMD178 (TFA)

• UNSPSC Description:

  CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development[1].

• Target Antigen:

  STAT

• Type:

  Peptides

• Related Pathways:

  JAK/STAT Signaling;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cmd178-tfa.html

• Purity:

  98.61

• Solubility:

  H2O : 2.5 mg/mL (ultrasonic)

• Smiles:

  OC(C(F)(F)F)=O.F[R](F)[K].[Y]OCC1=CC=CC=C1

• Molecular Weight:

  964.05

• References & Citations:

  [1]Price-Troska T, et, al. Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides. Invest New Drugs. 2019 Feb;37(1):9-16.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported