CMD178 (TFA)

• Description :

  CMD178 TFA is a lead peptide that consistently reduced the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling and inhibits Treg cell development[1].

• UNSPSC :

  12352209

• Target :

  STAT

• Type :

  Peptides

• Related Pathways :

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cmd178-tfa.html

• Purity :

  99.71

• Solubility :

  H2O : 2.5 mg/mL (ultrasonic)

• Smiles :

  OC(C(F)(F)F)=O.F[R](F)[K].[Y]OCC1=CC=CC=C1

• Molecular Formula :

  C48H60F3N9O9

• Molecular Weight :

  964.05

• References & Citations :

  [1]Price-Troska T, et, al. Inhibiting IL-2 signaling and the regulatory T-cell pathway using computationally designed peptides. Invest New Drugs. 2019 Feb;37 (1) :9-16.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported