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11-Hydroxycanthin-6-one

CAT: 0804-HY-116786-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-116786-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
11-Hydroxycanthin-6-one, a canthin-6-one alkaloid, is an antitumor agent which shows potent cytotoxic activity[1][2].
CAS Number
75969-83-4
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Drug Derivative
Type
Natural Products
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/11-hydroxycanthin-6-one.html
Solubility
10 mM in DMSO
Smiles
O=C1N2C3=C(N=CC=C3C4=C2C=CC=C4O)C=C1
Molecular Formula
C14H8N2O2
Molecular Weight
236.23
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Fukamiya N, et, al. Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives. Planta Med. 1987 Apr;53 (2) :140-3.|[2]Miyake K, et, al. Canthin-6-one alkaloids and a tirucallanoid from Eurycoma longifolia and their cytotoxic activity against a human HT-1080 fibrosarcoma cell line. Nat Prod Commun. 2010 Jan;5 (1) :17-22.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

Amalorin

Amalorin is an alkaloid and an organic heterotetracyclic compound.

CAS Number75969-83-4
PubChem CID337601
IUPAC Name1,6-diazatetracyclo[7.6.1.05,16.010,15]hexadeca-3,5(16),7,9,12,14-hexaene-2,11-dione
Molecular FormulaC14H8N2O2
Molecular Weight236.22
XLogP0.4
Topological Polar Surface Area49.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count18
Formal Charge0
Complexity699
SMILES
C1=CC(=O)C2=C3C=CNC4=C3N(C2=C1)C(=O)C=C4
InChI
InChI=1S/C14H8N2O2/c17-11-3-1-2-10-13(11)8-6-7-15-9-4-5-12(18)16(10)14(8)9/h1-7,15H
InChIKey
IZNXKZBIIFOWPU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Amalorin
CAS: 75969-83-4
CID: 337601
Formula: C14H8N2O2
MW: 236.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight236.22
XLogP30.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass236.058577502
Monoisotopic Mass236.058577502
Topological Polar Surface Area49.4 Ų
Heavy Atom Count18
Formal Charge0
Complexity699
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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