L-706000 (free base)

L-706000 (free base)

• CAS Number: 161799-18-4
• UNSPSC Description: L-706000 (MK 499) free base is a potent hERG channel blocker with an IC50 of 32 nM. L-706000 free base is a class III antiarrhythmic agent that can be used for the study of malignant ventricular tachyarrhythmias[1].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/l-706000-free-base.html
• Smiles: O[C@@H]1CC2(CCN([C@@](CCC3=C4)([H])CC3=CC=C4C#N)CC2)OC(C1=C5)=CC=C5N[S](C)(=O)=O
• Molecular Weight: 467.58
• References & Citations: [1]J S Mitcheson, et al. Trapping of a methanesulfonanilide by closure of the HERG potassium channel activation gate. J Gen Physiol. 2000 Mar;115(3):229-40. |[2]S Vickers, et al. Metabolism of MK-499, a class III antiarrhythmic agent, in rats and dogs. Drug Metab Dispos. 1998 May;26(5):388-95.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported