(s) -PF-4136309

CAT: 0804-HY-13245A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-13245A-01Size:5 mg
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Description
(s) -PF-4136309 is the isomer of PF-4136309 (HY-13245), and can be used as an experimental control. PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2.
CAS Number
[1372407-07-2]
Product Name Alternative
(s) -INCB8761
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CCR; Drug Isomer
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-pf-4136309.html
Concentration
10mM
Purity
98.93
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O[C@]1(CC[C@@](CC1)([H])N[C@@H]2CN(CC2)C(CNC(C3=CC=CC(C(F)(F)F)=C3)=O)=O)C4=NC=C(C=C4)C5=NC=CC=N5
Molecular Formula
C29H31F3N6O3
Molecular Weight
568.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Xue CB, et al. Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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