MC-DM1

• Description :

  MC-DM1 is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody agent conjugate (ADC) [1].

• CAS Number :

  [1375089-56-7]

• UNSPSC :

  12352203

• Hazard Statement :

  H302, H318, H410

• Target :

  Drug-Linker Conjugates for ADC

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mc-dm1.html

• Purity :

  99.50

• Solubility :

  DMSO : ≥ 200 mg/mL

• Smiles :

  C[C@]1([C@H](CC(N(C(C=C(C2)C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCCCCN(C4=O)C(C=C4)=O)=O)=O)[C@@]([C@@H]([C@](OC5=O)([H])C[C@]([C@@H](/C=C/C=C2\C)OC)(N5)O)C)([H])O1

• Molecular Formula :

  C42H55ClN4O12

• Molecular Weight :

  843.36

• Precautions :

  H302, H318, H410

• References & Citations :

  [1]Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28 (8) :1363-1370.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Maytansinoids