MC-DM1

• Description:

  MC-DM1 is a agent-linker conjugate composed of a potent microtubule-disrupting agent DM1 and a linker MC to make antibody agent conjugate (ADC) [1].

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H318, H410

• Target:

  Drug-Linker Conjugates for ADC

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mc-dm1.html

• Purity:

  99.50

• Solubility:

  DMSO : ≥ 200 mg/mL

• Smiles:

  C[C@]1([C@H](CC(N(C(C=C(C2)C=C3OC)=C3Cl)C)=O)OC([C@H](C)N(C)C(CCCCCN(C4=O)C(C=C4)=O)=O)=O)[C@@]([C@@H]([C@](OC5=O)([H])C[C@]([C@@H](/C=C/C=C2\C)OC)(N5)O)C)([H])O1

• Molecular Formula:

  C42H55ClN4O12

• Molecular Weight:

  843.36

• Precautions:

  H302, H318, H410

• References & Citations:

  [1]Shao S, et al. Site-specific and hydrophilic ADCs through disulfide-bridged linker and branched PEG. Bioorg Med Chem Lett. 2018 May 1;28 (8) :1363-1370.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Maytansinoids

• CAS Number:

  [1375089-56-7]